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Image Search Results
Journal: CNS Drugs
Article Title: Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies
doi: 10.1007/s40263-021-00811-2
Figure Lengend Snippet: Relationship between severity of COVID-19 disease, clinical scenarios, and use of specific psychotropic and COVID-19 therapies. ICU intensive care unit
Article Snippet: Lopinavir/ritonavir and darunavir/cobicistat pose the major concern in terms of clinically relevant interactions with psychotropic agents. Concomitant administration of protease inhibitors with haloperidol, quetiapine, ziprasidone, carbamazepine, midazolam and triazolam should be avoided because of increased toxicity. A low risk of clinically relevant interactions is expected with other
Techniques:
Journal: CNS Drugs
Article Title: Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies
doi: 10.1007/s40263-021-00811-2
Figure Lengend Snippet: Summary of the activity of the different COVID-19 therapies on CYP450 and on transporters. Relevant PD effects (QT prolongation) of both COVID-19 agents and of severe forms of COVID-19 are indicated
Article Snippet: Lopinavir/ritonavir and darunavir/cobicistat pose the major concern in terms of clinically relevant interactions with psychotropic agents. Concomitant administration of protease inhibitors with haloperidol, quetiapine, ziprasidone, carbamazepine, midazolam and triazolam should be avoided because of increased toxicity. A low risk of clinically relevant interactions is expected with other
Techniques: Activity Assay, Inhibition, Infection, In Vitro
Journal: CNS Drugs
Article Title: Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies
doi: 10.1007/s40263-021-00811-2
Figure Lengend Snippet: Proposed algorithm for the management of potential clinically relevant interactions between psychotropic medications and repurposed COVID-19 agents according to disease severity/stage of the infection. BZD benzodiazepine, DDIs drug–drug interactions, ICU intensive care unit, IL interleukin, TDM therapeutic drug monitoring
Article Snippet: Lopinavir/ritonavir and darunavir/cobicistat pose the major concern in terms of clinically relevant interactions with psychotropic agents. Concomitant administration of protease inhibitors with haloperidol, quetiapine, ziprasidone, carbamazepine, midazolam and triazolam should be avoided because of increased toxicity. A low risk of clinically relevant interactions is expected with other
Techniques: Infection
Journal: CNS Drugs
Article Title: Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies
doi: 10.1007/s40263-021-00811-2
Figure Lengend Snippet:
Article Snippet: Lopinavir/ritonavir and darunavir/cobicistat pose the major concern in terms of clinically relevant interactions with psychotropic agents. Concomitant administration of protease inhibitors with haloperidol, quetiapine, ziprasidone, carbamazepine, midazolam and triazolam should be avoided because of increased toxicity. A low risk of clinically relevant interactions is expected with other
Techniques: